Cell media change / Expanding cell culture / Picking of adherent spheroids
Please see the following Application examples.
Cell media change
In long-term spheroid culturing, refreshing cell media is a challenging step. CELL HANDLER™ solves this issue by transferring spheroids to new plates, thereby achieving a complete media change (Fig. 1).
Fig.1 Spheroid transfer from 384-well plate to 384-well plate (Success rate : 99%, N=200 wells)
* HT-29(Colorectal) * Tip with >180 µm in diameter is under development.
Expanding cell culture
Upscaling of cell culture requires transferring of cells or spheroids to plates with larger well sizes, which is done rapidly and efficiently by the CELL HANDLER™ (Fig. 2).
Fig.2 Spheroid transfer from 384-well plate to 96-well plate (Success rate : 98%, N=144 wells)
* HT-29(Colorectal) * Tip with >180 µm in diameter is under development.
Picking of adherent spheroids
Adherent spheroids are formed in circular shapes at the bottom of the Cell-able® plate. CELL HANDLER™ transfers these adherent spheroids with high precision.
Cell-able®
Fig. 3 Cell-able® to 384 well plate
* HT-29(Colorectal)
* "Cell-able" is a registered trademark of TOYO GOSEI CO., LTD..
* For research use only. Not for use in diagnostic or therapeutic procedures.
* The specifications are subject to change without notice.
* The above are the results of experiments in our laboratory. The results may vary depending on the work environment, cell type and so on.
Applications
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